Abstract摘要
Whileguidelinesprovideimportantinformationonhowtoapproachapatientinsepticshock,“manychallengesremain”forthemanagementofthesepatients.Inthisnarrativereview,thepaneldiscussesthechallengesinidentifyingtherighthemodynamictarget,optimizationoffluidtherapy,selectionofvasopressoragents,identificationofpatientswhomaybenefitfrominotropicagentsoronthecontrarybeta?blockade,anduseofsteroids.Theplaceformicrocirculation?targetedtherapyisdebatedaswellastheuseofalternativetechniques(bloodpurification)andtherapies(vitaminC).Theimplicationsofhemodynamicalterationsonantibioticdosesisdiscussed.Finally,thespecificchallengesinlow?andmiddle?in